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Polymorphisms in ABCB11 and ATP8B1 Associated with Development of Severe Intrahepatic Cholestasis in Hodgkin's Lymphoma

✍ Scribed by Blackmore, Laura; Knisely, A.S.; Hartley, Jane L.; McKay, Kirsten; Gissen, Paul; Marcus, Robert; Shawcross, Debbie L.


Book ID
122910335
Publisher
Elsevier
Year
2013
Tongue
English
Weight
458 KB
Volume
3
Category
Article
ISSN
0973-6883

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Progressive familial intrahepatic cholestasis (PFIC) types 1 and 2 are characterized by normal serum gamma-glutamyl transferase (GGT) activity and are due to mutations in ATP8B1 (encoding FIC1) and ABCB11 (encoding bile salt export pump [BSEP]), respectively. Our goal was to evaluate the features th