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Polymorphisms at regions 1p22.1 and 8q24 are risk markers for nonsyndromic cleft lip and/or palate (NSCL/P) in the Brazilian population


Book ID
119335879
Publisher
Elsevier
Year
2012
Tongue
English
Weight
132 KB
Volume
114
Category
Article
ISSN
2212-4403

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BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD

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## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2