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Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma

โœ Scribed by Rui Yang; Jing Qin; Bang H. Hoang; John H. Healey; Richard Gorlick

Book ID
107562705
Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
212 KB
Volume
466
Category
Article
ISSN
0009-921X

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Reduced folate carrier protein expressio
Reduced folate carrier protein expression in osteosarcoma : Implications for the prediction of tumor chemosensitivity
โœ Ilan Ifergan; Issac Meller; Josefin Issakov; Yehuda G. Assaraf ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 178 KB

## Abstract ## BACKGROUND Highโ€dose methotrexate (MTX) is an important component of current protocols for the treatment of osteosarcoma. Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein