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Polymorphism of C-terminal activation region 2 of Epstein-Barr virus latent membrane protein 1 in predicting distant failure and post-metastatic survival in patients with nasopharyngeal carcinoma

✍ Scribed by Ping-Ching Pai; Chen-Kan Tseng; Chi-Cheng Chuang; Kuo-Chen Wei; Sheng-Po Hao; Chuen Hsueh; Kai-Ping Chang; Ngan-Ming Tsang

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
298 KB
Volume
29
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

The C‐terminal activation region 2 (CTAR2) of Epstein‐Barr virus latent membrane protein 1 is the major site that correlates with metastasis‐related signaling pathway. The variation of CTAR2 sequence may affect the incidence of distant metastasis in patients with nasopharyngeal carcinoma (NPC).

Methods.

Two hundred forty‐nine specimens from consecutive patients with nonmetastatic NPC were collected. Amplification by polymerase chain reaction and sequence analysis of CTAR2 were performed. DNA sequence identical to the Cao strain was grouped as Cao CTAR2, whereas sequences differing from Cao made up non‐Cao CTAR2. Clinical characteristics and CTAR2 status were subjected to statistical analysis for distant metastasis.

Results.

Non‐Cao CTAR2 was associated with a statistically significant lower distance metastasis and superior survival rate. A combination of clinical stage and CTAR2 expression provided an accurate method of identifying high risk of metastasis.

Conclusion.

NPC patients with non‐Cao CTAR2 were less likely to have metastasis develop than those characterized by Cao CTAR2. © 2006 Wiley Periodicals, Inc. Head Neck 2007

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