Polymorphism in the 3′ untranslated region of the phenylalanine hydroxylase gene detected by enzyme mismatch cleavage: evolution of haplotypes

✍ Scribed by Susan J. Ramus; Richard G. H. Cotton

• Publisher: Springer
• Year: 1995
• Tongue: English
• Weight: 417 KB
• Volume: 96
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00210312

✦ Synopsis

A polymorphism was identified in 3' untranslated region of the phenylalanine hydroxylase gene using the newly described mutation detection method, enzyme mismatch cleavage. This polymorphism, 1546 G-->A, was linked to three mutations on several haplotype backgrounds. A group of haplotypes was identified as evolving from the one ancestral haplotype on which this base substitution occurred. The possible Celtic or Viking origin of this polymorphism is discussed.