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Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases

✍ Scribed by Shu Ye

Book ID
117640197
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
96 KB
Volume
19
Category
Article
ISSN
0945-053X

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## Abstract Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single guanine insertion polymorphism (2G) in the __MMP1__ promoter sequence at βˆ’1,607 creates an Ets binding site and thus results in enhancing transcriptional activity. This study aimed t