✦ LIBER ✦

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

✍ Scribed by Joanna K. Tarlow; Alexandra I. F. Blakemore; Andrew Lennard; Roberto Solari; Howard N. Hughes; Alexander Steinkasserer; Gordon W. Duff

Publisher: Springer
Year: 1993
Tongue: English
Weight: 263 KB
Volume: 91
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00217368

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✦ Synopsis

We have investigated the polymorphism in intron 2 of the interleukin-1 receptor antagonist gene and identified two new alleles of the system. We have shown that the polymorphism is caused by the variable copy number of an 86-bp sequence, by using the polymerase chain reaction and primers immediately flanking the repeat region, and by direct sequencing. The repeat region contains three potential protein-binding sites and therefore the variable copy number may have functional significance.