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Polymorphism in an Amyloid-Like Fibril-Forming Model Peptide

✍ Scribed by René Verel; Ivan T. Tomka; Carlo Bertozzi; Riccardo Cadalbert; Richard A. Kammerer; Michel O. Steinmetz; Beat H. Meier


Book ID
101567788
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
499 KB
Volume
47
Category
Article
ISSN
0044-8249

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Single crystal X-ray diffraction studies of a terminally blocked tripeptide Boc-Leu(1)-Aib(2)-Leu(3)-OMe 1 demonstrates that it adopts a bend structure without any intramolecular hydrogen bond. Peptide 1 self-assembles to form a supramolecular antiparallel b-sheet structure by various non-covalent i