Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines

Malignant glioma cells use MHC class II

Malignant glioma cells use MHC class II transactivator (CIITA) promoters III and IV to direct IFN-γ-inducible CIITA expression and can function as nonprofessional antigen presenting cells in endocytic processing and CD4+ T-cell activation

✍ Jeanne M. Soos; Jeffrey I. Krieger; Olaf Stüve; Chelsea L. King; Juan Carlos Pat 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 615 KB

## Abstract Malignant gliomas (MGs), lethal human central nervous system (CNS) neoplasms, contain tumor infiltrating lymphocytes (TIL). Although MHC class II molecules are frequently detected on MG cells, suggesting that they may be capable of antigen (Ag) presentation to CD4^+^ T cells, deficienci