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Polymorphic deletions of the GSTT1 and GSTM1 genes and susceptibility to bladder cancer

✍ Scribed by Antonio S. Salinas-Sánchez; Francisco Sánchez-Sánchez; María J. Donate-Moreno; Antonio Rubio-del-Campo; José M. Gimenez-Bachs; Juan G. Lorenzo-Romero; Leticia Serrano-Oviedo; Julio Escribano

Book ID
110923199
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
288 KB
Volume
107
Category
Article
ISSN
1464-4096

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## Abstract Isothiocyanates (ITCs) are nonnutrient compounds in cruciferous vegetables with anticarcinogenic properties. ITCs down‐regulate cytochrome P‐450 biotransformation enzyme levels, activate Phase II detoxifying enzymes and induce apoptosis. On the other hand, ITCs also serve as a substrate