𝔖 Bobbio Scriptorium
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Polymetallic macromolecules are potential contrast agents of improved efficiency

✍ Scribed by Frederich Cavagna; Claudio Luchinat; Professor Andrea Scozzafava; Zhicheng Xia

Book ID
102533297
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
285 KB
Volume
31
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The commercial synthetic homopolypeptide polyaspartate (average MW = 30,000, approximately 220 monomers) in solution quantitatively binds up to 40 mol Gd^2+^ ions per mole of polyaspartate. The water proton relaxivity of the solutions is far higher than that of clinically used or commonly investigated gadolinium(III) complexes. It is shown that polymetallic macromolecular complexes combine the high relaxing efficiency of monometallic macromolecular complexes with the favorable metal/ligand mass ratio of small monometallic complexes.

πŸ“œ SIMILAR VOLUMES

Improved synthesis of DOTA tetraamide li
Improved synthesis of DOTA tetraamide ligands for lanthanide(III) ions: A tool for increasing the repertoire of potential PARACEST contrast agents for MRI and/or fluorescent sensors
✍ Luis M. De LeΓ³n-RodrΓ­guez; Subha Viswanathan; A. Dean Sherry πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 165 KB

The synthesis of new DOTA tetraamide (DOTAMR 4 ) compounds is of great interest given their application in the formation of Ln(III) complexes as potential PARACEST contrast agents in MRI or fluorescent molecular probes. In this context amino acid and peptide DOTAMR 4 derivatives are particularly att