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Polymers for Control Freaks: Sequence-Defined Poly(amidoamine)s and Their Biomedical Applications

✍ Scribed by Laura Hartmann

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 381 KB
Volume: 212
Category: Article
ISSN: 1022-1352
DOI: 10.1002/macp.201000479

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✦ Synopsis

Abstract

A novel synthetic strategy towards monodisperse, sequence‐defined polymers is presented. This technique was applied for the synthesis of a set of polymer carriers for DNA delivery combining monodisperse, sequence‐defined PAA segments with PEO blocks. These precision polymers are sequentially assembled from a library of building blocks, enabling programmed interactions and functions by sequence‐specific positioning of different functionalities. Due to the absence of chemical and molecular‐weight distributions in the multifunctional segments, exact correlation of the monomer sequence and (bio)properties is attainable. This is demonstrated by the interactions with plasmid DNA, investigating the dsDNA complexation and condensation properties in dependence of the monomer sequence. magnified image

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## Abstract Poly(amidoamine)s (PAAs) have received significant attention due to their good biocompatibility and fast biodegradation profile which gives these polymers high potential in biomedical applications. Conventional synthesis of PAAs via aza‐type Michael addition reaction of primary amines t