Polymers as Reagents in Organic Synthesis

✍ Scribed by Prof. Dr. C. G. Overberger; Dr. K. N. Sannes

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 488 KB
• Volume: 13
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.197400991

✦ Synopsis

Abstract

Polymeric reagents offer a range of unique advantages. Intramolecular reactions, such as the cyclization of peptides or Dieckmann cyclizations, can be brought about by attaching the reactive molecules at remote points along a polymer chain. In contrast, if the reactive molecules are anchored in close proximity on a polymeric support then intermolecular reactions occur, as demonstrated for a ketone synthesis. Apart from such proximity effects, cooperative effects can also be exploited, e.g. in the formation of a 2:1 complex of a crown ether and an alkali metal ion. The hydrolysis of an ester with polyvinylimidazole provides a detailed illustration of hydrophobic interactions. The simple separation of polymer‐bound and low‐molecular compounds by filtration is another significant advantage.