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Polymerization of optical isomers of phenylalanine N-carboxyanhydride by poly (N-methylalanine) diethylamide

✍ Scribed by Yukio Imanishi; Kazuya Kugimiya; Toshinobu Higashimura

Publisher
Wiley (John Wiley & Sons)
Year
1974
Tongue
English
Weight
400 KB
Volume
13
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

In the polymerization of phenylalanine N‐carboxyanhydride (NCA) using poly(N‐methyl‐L‐or DL‐alanine) diethylamide as initiator, the polymerization rate was L‐NCA ≃ D‐NCA > DL‐NCA. This is a new type of selective polymerization and indicates the incompleteness of earlier investigations to study the asymmetrically selective polymerization without D‐NCA. Neither secondary structure nor optical activity of the polymeric initiator is a reason for the selectivity. Hence the cause for the selectivity was sought in the properties of the NCA's in solution. However, the selectivity was not observed in the polymerization initiated by poly(L‐phenylalanine) dimethylamide. The importance of the initiator being a secondary amine type was suggested. The experimental results are discussed on the basis of these considerations.

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