Polymeric Micelles and Nanoparticles from Block and Statistical Poly((RS)-3,3-dimethylmalic acid) Derivatives: Preparation and Characterization

✍ Scribed by Farid Ouhib; Solo Randriamahefa; Véronique Wintgens; Philippe Guérin; Christel Barbaud

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 136 KB
• Volume: 5
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200400177

✦ Synopsis

Abstract

Summary: Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring‐opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly((RS)‐3,3‐dimethylmalic acid) and hydrophobic poly(hexyl (RS)‐3,3‐dimethylmalate) segments. Micelles obtained from a well‐defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM).

Electron transmission microphotography of nanoparticles of PDMMLAH~30~‐co‐He~70~ 4.

magnified imageElectron transmission microphotography of nanoparticles of PDMMLAH~30~‐co‐He~70~ 4.