## Abstract Mucopolysaccharidosis Type I, Hurler's Syndrome, is a lysosomal storage disorder that affects the brain. The missing enzyme, α‐L‐iduronidase (IDUA), does not cross the blood‐brain barrier (BBB). To enable BBB transport of the enzyme, human IDUA was fused to the carboxyl terminus of the
✦ LIBER ✦
Polymeric micelles anchored with TAT for delivery of antibiotics across the blood–brain barrier
✍ Scribed by Lihong Liu; Subbu S. Venkatraman; Yi-Yan Yang; Kun Guo; Jia Lu; Beiping He; Shabbir Moochhala; Lijing Kan
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2008
- Tongue
- English
- Weight
- 273 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0006-3525
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## Abstract Neurotrophins, such as brain derived neurotrophic factor (BDNF), do not cross the blood–brain barrier (BBB). Certain monoclonal antibodies (MAb) to the human insulin receptor (HIR) do cross the BBB via receptor‐mediated transport, and can act as a molecular Trojan horse to ferry across