Polymeric matrix for drug delivery: Honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel

✍ Scribed by MaLing Gou; ChangYang Gong; Juan Zhang; XiuHong Wang; XianHuo Wang; YingChun Gu; Gang Guo; LiJuan Chen; Feng Luo; Xia Zhao; YuQuan Wei; ZhiYong Qian

• Book ID: 102296010
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 263 KB
• Volume: 9999A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.32546

✦ Synopsis

Abstract

In this article, we demonstrated a novel injectable polymer matrix: honokiol (HK) loaded poly (ϵ‐caprolactone)‐poly(ethylene glycol)‐poly(ϵ‐caprolactone) (PCL‐PEG‐PCL, PCEC) nanoparticles in thermosensitive poly(ethylene glycol)‐poly(ϵ‐caprolactone)‐poly(ethylene glycol) (PEG‐PCL‐PEG, PECE) hydrogel for the drug local delivery. First, HK, as a model hydrophobic drug, was loaded into PCL‐PEG‐PCL nanoparticles by emulsion solvent evaporation method to overcome its poor water solubility. Then, the HK‐loaded PCEC nanoparticles (HK‐PCEC) were incorporated into thermosensitive PEG‐PCL‐PEG hydrogel, which was sol at low temperature and could gel as a depot for sustained release of drug in situ after topical injection. The HK‐PCEC incorporated PECE hydrogel (HK‐PCEC‐PECE) was biodegradable and could be gradually eliminated from the injection site in about 2 weeks after subcutaneously injected into mice. The in vitro release studies indicated that HK could be released from HK‐PCEC and HK‐PCEC‐PECE in a sustained manner. Such biodegradable smart drug‐delivery system might have great potential application in injectable hydrophobic drug local delivery system. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010