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Polymer–drug conjugates as nano-sized medicines

✍ Scribed by Fabiana Canal; Joaquin Sanchis; María J Vicent

Book ID
113553620
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
441 KB
Volume
22
Category
Article
ISSN
0958-1669

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An amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight methoxy poly(ethylene glycol) (PEG) (i.e., 2 kDa) to docetaxel (DTX) through an ester linkage. The PEG-DTX conjugate having a critical micelle concentration of 0.88 mg/mL was used to form nano-sized micelles, wi