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Polymerase chain reaction and viral culture techniques to detect HSV in small volumes of cerebrospinal fluid; an experimental mouse encephalitis study

✍ Scribed by R.H. Boerman; E.P.J. Arnoldus; A.K. Raap; B.R. Bloem; M. Verhey; G. van Gemert; A.C.B. Peters; M. van der Ploeg

Book ID: 119114705
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 662 KB
Volume: 25
Category: Article
ISSN: 0166-0934
DOI: 10.1016/0166-0934(89)90032-3

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Polymerase chain reaction for early detection of HSV-DNA in cerebrospinal fluid: An experimental mouse encephalitis study

✍ Rudolf H. Boerman; Edo P. J. Arnoldus; A. C. Boudewijn Peters; Bastiaan R. Bloem 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 899 KB

A series of experiments was carried out using a mouse HSV-1 encephalitis model for detecting HSV-DNA in CSF by the polymerase chain reaction (PCR). The results were correlated with the time period after corneal inoculation, clinical signs and symptoms, and progression of infection in brain tissue (a