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Polymer Macro- and Micro-Gel Beads: Fundamentals and Applications

✍ Scribed by Nussinovitch


Publisher
Springer
Year
2010
Tongue
English
Leaves
322
Category
Library

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✦ Synopsis


Beads made from Egyptian faience have been excavated from grave deposits (c. 4000–3100 BC), together with beads of glazed steatite (a soft rock) and of se- precious stones such as turquoise, carnelian, quartz, and lapis lazuli. Information on these and many more ancient beads used for ornaments and jewelry, ritual ceremonies, as art artifacts and gifts for amorous women throughout history, and descriptions of the raw materials (e. g. , glass, bone, precious and other stones) and manufacturing technologies used for their production can be located in many references. Many books are devoted to the description of beads that are not of water-soluble polymer origin, techniques for their production, their art, value, and distribution, re?ecting the wealth of information existing in this ?eld of science and art. On the other hand, there are no books fully devoted to the fascinating topic of hydrocolloid (polymeric) beads and their unique applications. A few books c- tain scattered chapters and details on such topics, while emphasizing the possibility of locating fragments of information elsewhere; however, again, there is no book that is solely devoted to hydrocolloid beads and their versatile applications. In the meantime, the use of water-soluble hydrocolloid beads is on the rise in many ?elds, making a book that covers both past and novel applications of such beads, as well as their properties and ways in which to manipulate them, crucial.

✦ Table of Contents


Preface
Chapter 1
: Physical Properties of Beads and Their Estimation
Chapter 2
: Bead Formation, Strengthening, and Modification
Chapter 3: Methods and Mathematical Models for the Drying of Polymeric Beads
Chapter 4
: Food and Biotechnological Applications for Polymeric Beads and Carriers
Chapter 5
: Medicinal Applications of Hydrocolloid Beads
Chapter 6
: Dry Bead Formation, Structure, Properties, and Applications
Chapter 7
: Liquid-Core Beads and Their Applications in Food, Biotechnology, and Other Fields
Chapter 8
: Beads as Drug Carriers
Chapter 9
: Beads and Special Applications of Polymers for Agricultural Uses
Chapter 10
: Beads for Environmental Applications
Acknowledgments
Contents
About the Author
List of Figures
1 Physical Properties of Beads and Their Estimation
1.1 Introduction
1.2 Bead Size and Shape
1.2.1 General
1.2.2 Size of Drops and Beads
1.2.3 Bead Shape
1.2.3.1 Roundness
1.2.3.2 Sphericity
1.2.3.3 Average Projected Area and Sphericity
1.2.4 Bead Volume and Surface Area
1.2.4.1 Specific Surface Area
1.2.4.2 Volume Estimation Methods
1.3 Bead Density, Porosity, and Structure
References
2 Bead Formation, Strengthening, and Modification
2.1 Introduction
2.2 Entrapment
2.3 Single-Step Methods
2.3.1 Agar
2.3.2 Agarose
2.3.3 -Carrageenan
2.3.4 Alginates
2.3.5 Chitosan
2.3.6 Cellulose
2.3.7 Proteins
2.3.7.1 Collagen
2.3.7.2 Gelatin
2.3.7.3 Hen Egg White
2.3.8 Synthetic Polymers
2.3.8.1 Polyacrylamide
2.3.8.2 Polyvinyl Alcohol (PVA)
2.3.8.3 Other Synthetic Polymers
2.4 Two-Step Methods
2.5 Cell Immobilization by Electrostatic Method
References
3 Methods and Mathematical Models for the Drying of Polymeric Beads
3.1 Introduction
3.2 Methods for Drying Polymeric Gel Beads
3.2.1 General
3.2.2 Air-Drying
3.2.3 Fluidized-Bed and Microwave-Assisted Fluidized-Bed Drying
3.2.4 Freeze-Drying
3.2.5 Freeze-Dried Biological Products
3.3 Drying of Dosage Forms Made of Drug Dispersed in a Polymer
3.3.1 Mathematical Model
3.3.2 Numerical Model
3.3.3 Drying a Polymer Bead with Shrinkage
References
4 Food and Biotechnological Applications for Polymeric Beads and Carriers
4.1 Introduction
4.2 Amino Acid Production
4.2.1 L
-Aspartic Acid
4.2.2 L
-Alanine
4.2.3 L
-Phenylalanine
4.3 Organic Acid Fermentation and Conversion
4.3.1 General
4.3.2 Citric Acid
4.3.3 Malic Acid
4.3.4 Gluconic Acid
4.3.5 Lactic Acid
4.4 Ethanol, Wine, Vinegar, Sake, and the Like
4.4.1 Vinegar
4.4.2 Soft Sake
4.4.3 Malolactic Fermentation
4.4.4 Removal of Urea from Sake and Wine by Immobilized Acid Urease
4.4.5 Beer Brewing Using an Immobilized Yeast Bioreactor System
4.5 Soy Sauce
4.6 The Milk Industry
4.6.1 Immobilization in the Milk Industry
4.6.2 Hydrolysis of Lactose in Milk
4.6.3 Antibiotic Residues in Milk
4.7 Miscellaneous Flavor Materials and Aroma Compounds
4.7.1 Biotransformation from Geraniol to Nerol
4.7.2 Limonin
4.7.3 Ξ²-Ionone
4.7.4 Naringin
4.7.5 Methyl Ketone (Blue Cheese Flavor) as a Flavor Molecule from Higher Fungi
4.7.6 Capsaicin
4.7.7 Vanillin
4.7.8 Japanese Seasoning
4.8 Miscellaneous Applications
4.8.1 Production of Oligosaccharides
4.8.2 Preservatives and Bacteriocins
4.8.3 Xylitol Production
4.8.4 Carotenoids and Leucrose
4.8.5 cis,cis -Muconic Acid (MA)
4.9 Various Industrial Options
4.9.1 Fuel Ethanol Production
4.9.2 Application of Gels for Separation Matrices
4.9.3 Bioartificial Organs
4.9.4 Insect Cell Immobilization
References
5 Medicinal Applications of Hydrocolloid Beads
5.1 Introduction
5.2 Encapsulation of Cells in Hydrogels
5.3 Stem Cells in Bead Environments
5.4 Charged Hydrogel Beads as New Microcarriers for Cell Culture
5.5 Potential Support for Endothelial Cells
5.6 Vaccine Delivery
5.7 Crosslinked Chitosan Beads: Different Medicinal Functions
5.8 Mucoadhesive Beads and Their Applications
5.8.1 General
5.8.2 Eyes
5.8.3 Alimentary System
5.9 Polyelectrolyte Complexes
5.10 Soft Tissue Regeneration
References
6 Dry Bead Formation, Structure, Properties, and Applications
6.1 Introduction
6.2 General Properties of Cellular Solids
6.3 Manufacturing Methods for Hydrocolloid Cellular Solids
6.3.1 Drying Bicarbonate-Containing Gels After Acid Diffusion
6.3.2 Cellular Solids Produced by Fermentation
6.3.3 Enzymatically Produced Cellular Solids
6.3.4 Inclusion of Oil in Cellular Solids
6.3.5 Porosity Control in Cellular Solids
6.4 Structure of Cellular Solids
6.5 Mechanical Properties of Cellular Solids
6.5.1 Compression of Cellular Solids
6.5.2 Models for Describing Stress--Strain Behavior
6.5.3 Elastic Properties of Cellular Materials
6.5.4 Layered Cellular Solids and Compressibility of Cellular Particulates
6.5.5 Acoustic Properties of Cellular Solids
6.6 Applications of Cellular Solids
6.6.1 Hydrocolloid Cellular Solids as a Carrier for Vitamins
6.6.2 Dried Gel Beads as Study Models and for Separation
6.6.3 Special Dry Beads for Water Treatment
6.6.4 Matrices Entrapping Hydrocolloid Cellular Beads
6.7 Hydrocolloid Cellular Carriers for Agricultural Uses
6.7.1 General
6.7.2 Preservation of Biocontrol Agents in a Viable Form by Dry Cellular Bead Carriers
6.7.3 Dry Carriers' Capacity to Protect Biocontrol Agents Against UV Light
6.7.4 Textural Features of Dried Hydrocolloid Beads
References
7 Liquid-Core Beads and Their Applications in Food, Biotechnology, and Other Fields
7.1 Introduction
7.2 General
7.3 Soft Gelatin Capsules
7.4 Liquid-Core Capsules
7.4.1 Liquid-Core Hydrocolloid Capsules
7.4.2 Synthetic and Additional Liquid-Core Capsules
7.5 Oil-Core Hydrocolloid Capsules
7.6 Biotechnological Applications of Liquid-Core Capsules
7.6.1 Growth of Microorganisms in Liquid-Core Capsules
7.6.2 Activity of Enzymes Within Liquid-Core Capsules
7.7 Special Food Applications
7.7.1 Jelly-Like Foods
7.7.2 Fruit Products
7.7.3 Encapsulating Aroma and Health Compounds
7.7.4 Other Foods
7.8 Agricultural Uses of Liquid-Core Capsules
7.9 Environmental Uses of Liquid-Core Capsules
7.10 Special Applications of Liquid-Core Capsules
7.10.1 Stop-Smoking Aids
7.10.2 The Beauty Industry---Removal of Body Hair
7.10.3 The Paper Industry
References
8 Beads as Drug Carriers
8.1 Introduction
8.2 Controlled Drug Release
8.3 Gels in Drug-Delivery Systems
8.4 Dual Drug-Loaded Beads
8.5 Drug Release from Beads
8.5.1 Albumin Beads
8.5.2 Alginate Beads
8.5.2.1 General
8.5.2.2 Alginate Beads Reinforced by Chitosan
8.5.2.3 Calcium Alginate/PNIPAAM Beads
8.5.3 Chitosan Beads
8.5.3.1 General
8.5.3.2 Chitosan--Tripolyphosphate Beads
8.5.3.3 Chitosan Microspheres in Treating Rheumatoid Arthritis
8.5.3.4 Carboxymethyl Chitosan Beads
8.5.4 Gelatin
8.5.4.1 Gelatin Microspheres
8.5.4.2 Dextran as a Crosslinker of Gelatin Beads
8.5.5 Modified Starch Microspheres
8.5.6 Dextran Beads
8.5.7 Cellulose Hydrogels
8.5.8 Gellan Beads
8.5.9 Guar Beads
8.5.10 Pectin
8.5.10.1 General
8.5.10.2 Pectin Beads
8.5.10.3 Pectin Beads for Colon-Specific Drug Delivery
8.5.10.4 Pectin--Chitosan Beads
8.5.11 Modified Poly(Vinyl Alcohol) Microspheres
8.5.12 Biodegradable Hydrogels Based on Polyesters
8.5.13 Hydrogels with Degradable Crosslinking Agents
8.5.13.1 Hydrogels Crosslinked with Small Molecules
8.5.13.2 Hydrogels Crosslinked with Azo Reagents
8.5.13.3 Hydrogels Crosslinked with Albumin
8.5.13.4 Hydrogels with Biodegradable Pendant Chains
8.5.14 Floating Beads
8.5.15 Xyloglucan Beads
References
9 Beads and Special Applications of Polymers for Agricultural Uses
9.1 Introduction
9.2 Immobilization of Plant Cell Suspensions and Single Seeds
9.3 Carriers for Slow Release of Bacteria that Affect Plant Growth
9.4 Inoculation of Seedlings and Plants with Beads Containing Fungal Inoculum
9.5 Joint Immobilization of Plant Growth-Promoting Bacteria and Green Microalgae
9.6 Cryopreservation by Encapsulation/Dehydration Technique
9.7 Controlled Release of Agricultural Chemicals
9.8 Biotechnological Applications
9.8.1 General
9.8.2 Gene-Delivery Systems Using Beads
9.8.3 Bioactive Bead Method for Obtaining Transgenic Plants
9.8.4 Synthetic Seed Technology
9.9 Unique Applications of Polymers
9.9.1 Superabsorbent Polymers
9.9.2 Seed Coating
References
10 Beads for Environmental Applications
10.1 Introduction
10.2 Water Treatments
10.2.1 General
10.2.2 Wastewater Treatment by Anaerobic Fixed Bed Reactor
10.2.3 Wastewater Treatment Using Immobilized Microorganisms
10.2.4 Arsenic Removal from Water
10.2.5 Chitosan and Removal of Heavy Metal Ions
10.2.6 Water Denitrification
10.2.7 Anaerobic Ammonium Oxidation
10.3 Soil Treatments
10.3.1 General
10.3.2 Agrochemicals
10.3.3 Controlled Release of Pesticides into Soils
10.3.4 Sustained Release of a Fungicide
10.4 Air Pollution
10.4.1 General
10.4.2 Sampling Air
10.4.3 Determination of Trace Contaminants in Air by Concentration on Porous Polymer Beads
10.5 Miscellaneous
10.5.1 Biodegradation
10.5.2 Carbon Nanotubes
10.5.3 Removal by Microalgae
References
Index


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