Polymer-bound triphenylphosphine as traceless reagent for mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols and alcohols

✍ Scribed by Ashok Rao Tunoori; Dinah Dutta; Gunda I. Georg

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 202 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01988-1

✦ Synopsis

The synthesis of aryl ethers from phenols and alcohols using polymer-bound triphenylphosphine and diethyl azodicarboxylate (DEAD) is described. The polymer-bound triphenylphosphines are easily removed by filtration from the reaction products. This method is operationally simple and provides the products with high purity and in good yields.