✦ LIBER ✦
Polymer-assisted solution phase synthesis: a general method for sequestration of byproducts formed from activated acyl-transfer reactants
✍ Scribed by John J. Weidner; John J. Parlow; Daniel L. Flynn
- Book ID
- 104260379
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 251 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Typical amide bond-forming reactions involving amines with activated esters are purified by the use of complementary molecular reactivity/molecular recognition (CMR/R) resins, which sequester both the excess activated ester and the byproducts (leaving group) generated. It is also shown by HPLC analysis that this strategy effectively removes many of the common byproducts generated from reactions involving activated esters, carbonates, and carbamates.