Polymer and Cell Dynamics: Multiscale Modeling and Numerical Simulations

✍ Scribed by Prof. Dr. Wolfgang Alt, Prof. Dr. Mark Chaplain, Prof. Dr. Michael Griebel (auth.), Prof. Dr. Wolfgang Alt, Prof. Dr. Mark Chaplain, Prof. Dr. Michael Griebel, Dr. Jürgen Lenz (eds.)

• Publisher: Birkhäuser Basel
• Year: 2003
• Tongue: English
• Leaves: 305
• Series: Mathematics and Biosciences in Interaction
• Edition: 1
• Category: Library

✦ Synopsis

Polymer and cell dynamics play an important role in processes like tumor growth, metastasis, embryogenesis, immune reactions and regeneration. This volume – based on an international workshop on numerical simulations of polymer and cell dynamics in Bad Honnef (Germany) in 2000 – provides an overview of the relevant mathematical and numerical methods, their applications and limits. The contributions are from the fields of applied and numerical mathematics, scientific computing, theoretical physics, molecular biophysics, cell and molecular biology as well as chemical and biomedical engineering. The volume will be of interest to scientists and advanced undergraduates in the fields of biotechnology, biomedicine, applied mathematics, biomathematics, biophysics and bioinformatics.

✦ Table of Contents

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Introduction to Part I....Pages 3-5
Molecular Dynamics Studies of Micelle and Capsid Self-assembly....Pages 7-17
A Functional Study on Saposin B and C Using Experimentally Validated Models....Pages 19-27
A Review of the Morph Server and the Macromolecular Motions Database: A Standardized System for Analyzing and Visualizing Macromolecular Motions in a Database Framework....Pages 29-42
Front Matter....Pages 43-43
Introduction to Part II....Pages 45-48
Brownian Dynamics of Flexible Polymers in Flow....Pages 49-68
A Microscopic Model for the Dynamics of Actin Filaments in Motility Assays and its Numerical Simulation....Pages 69-74
Multiparticle Modeling of Actin-Myosin Networks: From Molecular Interactions to Cell Motility....Pages 75-89
Analysis of Cell Motility Combining Cytomechanical Model Simulations and an Optical Flow Method....Pages 91-112
Micropipet Aspiration of the Human Neutrophil....Pages 113-124
Physical-object-oriented 3D Simulations of Cell Deformations and Migration....Pages 125-138
Front Matter....Pages 139-139
Introduction to Part III....Pages 141-144
Computational Modeling of Blood Clotting: Coagulation and Three-dimensional Platelet Aggregation....Pages 145-154
Space- and Time-resolved Simulations of Processes in Biofilm Systems on a Microscale....Pages 155-167
On Selected Individual-based Approaches to the Dynamics in Multicellular Systems....Pages 169-203
Individual-based Models of Cohort Migration in Cell Cultures....Pages 205-219
Interactive Movement, Aggregation, and Swarm Dynamics....Pages 221-241
A Discrete-cell Model of Tissue-equivalent Compaction....Pages 243-250
A Hybrid Discrete-continuum Technique for Individual-based Migration Models....Pages 251-259
Application of the Hybrid Discrete-continuum Technique....Pages 261-279
Back Matter....Pages 281-308

✦ Subjects

Mathematical and Computational Biology; Simulation and Modeling