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Polylactide-polyglycolide delivery system for physostigmine

✍ Scribed by Munir A. Hussain; Joseph A. Mollica

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
274 KB
Volume
82
Category
Article
ISSN
0022-3549

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✦ Synopsis

Cholinergic deficits in Alzheimer's disease have been well documented. Choline acetyltransferase and acetylcholinesterase are consistently reduced in the brain in presenile and senile dementia of the Alzheimer type.'-4 Physostigmine appears to improve memory function in patients with Alzheimer's disease.5.6 Physostigmine is effective parenterally at doses of 5 1 mg,7 and exhibits a very short half-life in human plasma after intravenous (iv) (0.4 h), intramuscular, and subcutaneous (sc) administrations (0.6 h),S and in rat plasma after iv administration (0.6 h1.9 It was suggested that until there is a long-term administration method for cholinomimetics such as physostigmine, it will

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