✦ LIBER ✦

Polyketide library synthesis: Conformational control in extended polypropionates

✍ Scribed by Ian Paterson; Jeremy P. Scott

Book ID: 104258055
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 232 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01752-8

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✦ Synopsis

The stereoregular heptapropionates 1 and 2 display contrasting conformational properties. The mutually reinforcing conformational determinants in hexol 1 lead to the population of essentially a single extended conformer with a helical twist.

📜 SIMILAR VOLUMES

ChemInform Abstract: Polyketide Library

ChemInform Abstract: Polyketide Library Synthesis: Conformational Control in Extended Polypropionates.

✍ I. PATERSON; J. P. SCOTT 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB

Polyketide library synthesis: Iterative

Polyketide library synthesis: Iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one

✍ Ian Paterson; Jeremy P. Scott 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 240 KB

The heptapropionates 5 and 20 were synthesised by iterative application of the boronmediated aldol reaction of ethyl ketone (R)-4 and subsequent reduction. Polyketide library diversification was realised by varying the ketone configuration and substitution in the aldol bond constructions.

ChemInform Abstract: Polyketide Library

ChemInform Abstract: Polyketide Library Synthesis: Iterative Assembly of Extended Polypropionates Using (R)- and (S)-1-(Benzyloxy)-2-methylpentan-3-one

✍ I. PATERSON; J. P. SCOTT 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB

Building a Small Polypropionate Library.

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✍ Arjona, Odón; Menchaca, Roberto; Plumet, Joaquín 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 202 KB

ChemInform Abstract: Laboratory Emulatio

ChemInform Abstract: Laboratory Emulation of Polyketide Biosynthesis: An Iterative, Aldol-Based, Synthetic Entry to Polyketide Libraries Using (R)- and (S)-1-(Benzyloxy)-2-methylpentan-3-one, and Conformational Aspects of Extended Polypropionates.

✍ Ian Paterson; Jeremy P. Scott 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 41 KB

Group 4 Metals in Polyketide Synthesis:

Group 4 Metals in Polyketide Synthesis: A Convergent Strategy for the Synthesis of Polypropionate-Derived (E,E)-Trisubstituted 1,3-Dienes.

✍ Heidi L. Shimp; Glenn C. Micalizio 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 32 KB 👁 3 views

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