✦ LIBER ✦

Poly(hydroxyethyl methacrylate)-Based Macroporous Hydrogels with Disulfide Cross-Linker

✍ Scribed by M. Andac; F. M. Plieva; A. Denizli; I. Yu. Galaev; B. Mattiasson

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 451 KB
Volume: 209
Category: Article
ISSN: 1022-1352
DOI: 10.1002/macp.200700467

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Biodegradable supermacroporous PHEMA cryogels were produced by combining two crosslinkers, poly(ethylene glycol) diacrylate and a newly developed disulfide water soluble crosslinker, N,N′‐bis(methacryloyl)‐L‐cystine. The biodegradable PHEMA cryogels were prepared with gel fraction yields up to 70% and were characterized by highly interconnected pores of micrometer size and good mechanical stability. When subjected to reductive agents like DTT, the biodegradable PHEMA cryogels disintegrated into small pieces. The rate of disintegration was controlled by the crosslinking density in the cryogels and the DTT concentration.

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