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Polyglutamine diseases: protein cleavage and aggregation

✍ Scribed by Huda Y Zoghbi; Harry T Orr

Book ID
114314137
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
79 KB
Volume
9
Category
Article
ISSN
0959-4388

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## Abstract Spinocerebellar Ataxia Type 3 (SCA3) is one of nine polyglutamine (polyQ) diseases that are all characterized by progressive neuronal dysfunction and the presence of neuronal inclusions containing aggregated polyQ protein, suggesting that protein misfolding is a key part of this disease