Polyglucosan bodies in sural nerve biopsies

✍ Scribed by H. L. S. M. Busard; A. A. W. M. Gabreëls-Festen; M. A. Hof; W. O. Renier; F. J. M. Gabreëls

• Book ID: 104709166
• Publisher: Springer-Verlag
• Year: 1990
• Tongue: English
• Weight: 618 KB
• Volume: 80
• Category: Article
• ISSN: 0001-6322
• DOI: 10.1007/bf00294618

✦ Synopsis

The presence of polyglucosan bodies in sural nerves collected over a 16-year period was studied in relation to age, sex, presence of polyneuropathy, and concomitant presence of central nervous system disorder. Polyglucosan bodies have been seen in only one patient without a polyneuropathy. This patient was suffering from Lafora's disease. In all other sural nerves positive for polyglucosan bodies a polyneuropathy was present. Within this group the prevalence of polyglucosan bodies was positively correlated with age, and if a central nervous system disorder was associated, this prevalence was more distinct. With semiquantitative measurements of the surface of polyglucosan bodies a significant correlation was found between age and percentage of large bodies.