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Polygenic susceptibility to prostate and breast cancer: implications for personalised screening

โœ Scribed by Duffy, S W; Chowdhury, S; Dent, T; Burton, H; Neal, D E; Pashayan, N; Easton, D F; Eeles, R; Pharoah, P


Book ID
109838743
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
377 KB
Volume
104
Category
Article
ISSN
0007-0920

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## Abstract Susceptibility to breast cancer is likely to be the result of susceptibility alleles in many different genes. In particular, one segregation analysis of breast cancer suggested that disease susceptibility in noncarriers of BRCA1/2 mutations may be explicable in terms of a polygenic mode