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Polyfunctional macroheterocycles. 7. Synthetic enzyme analogs. synthesis of 16- and 22-membered nitrogen and sulfur crown compounds containing exocyclic histamine and histidine fragments and carboxyl groups

✍ Scribed by M. G. Voronkov; V. N. Knutov; O. N. Shevko; M. K. Butin

Publisher: Springer US
Year: 1993
Tongue: English
Weight: 237 KB
Volume: 29
Category: Article
ISSN: 0009-3122
DOI: 10.1007/bf00528648

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The acylation of 1,5-diamino-, 1,5-bis(2-phenylethylamino)-, and 1,5-bis(2-methoxycarbonylethylamino)-3thiapentanes with adipic and phthalic acid dichlorides, as well as oxalyl chloride, leads to, respectively, 13-, 22-, and 18-membered macroheterocycles containing exocyclic methoxycarbonyl and phen