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Polyfunctional Aliphatic Compounds. V. The Cyclization of Dinitriles by Halogen Acids. A New Synthesis of Imidazoles

โœ Scribed by Johnson, Francis; Nasutavicus, W. A.


Book ID
121382097
Publisher
American Chemical Society
Year
1964
Tongue
English
Weight
666 KB
Volume
29
Category
Article
ISSN
0022-3263

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A method for the synthesis ofaza-crown compounds by the intramolecular cyclization of co-amino acids with subsequent reduction of the lactam to a macrocyclic amine was developed. 1,8-Diazacyclotetradecane and 1,8dioxa-4,11-diazacyclotetradecane were synthesized in preparative yields. The structural