Poly(fumaric-co-sebacic) microspheres as oral drug delivery systems

✍ Scribed by D. Chickering; J. Jacob; E. Mathiowitz

• Book ID: 102651996
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 667 KB
• Volume: 52
• Category: Article
• ISSN: 0006-3592
• DOI: 10.1002/(sici)1097-0290(19961005)52:1<96::aid-bit9>3.0.co;2-u

✦ Synopsis

The current study focuses on the development of bioadhesive oral delivery systems based on bioerodible polyanhydrides. The polymers were studied and characterized using a novel tensiometer based on a very sensitive electrobalance. The system was designed t o mimic in vivo interactions, thus all experiments were conducted with freshly excised tissue immersed in physiological saline at 37°C. Poly(fumaric-co-sebacic) [P(FA:SA)I was found to be the most bioadhesive polymer from a series of different thermoplastic materials evaluated. Correlation with in vivo performance was investigated by determining gastrointestinal (GI) residence time of bariumloaded microspheres. Residence times of 24 to 36 h provided a strong indication that these microspheres were good candidates for bioadhesive drug delivery systems. To evaluate the effect of these materials on bioavailability, the anticoagulant drug, dicumarol, was encapsulated. Systemic blood levels demonstrated increased bioavailability for the encapsulated dicumarol formulation as compared with unencapsulated drug.