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Polyfluoroalkyl- substituted 1-amino-1,2,3-triazoles

✍ Scribed by G.G. Bargamov; M.D. Bargamova


Book ID
107794610
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
250 KB
Volume
79
Category
Article
ISSN
0022-1139

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A robust, regioselective synthesis of 3-amino-1,2,4-triazoles is described. This reaction employs a key intermediate 2, which is coupled to carboxylic acids in good yields to afford intermediates 3a-d. These entities, in turn, react with a variety of hydrazines or hydrazine hydrochlorides to provide