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Poly(ethylene-glycol)-supported proline: a recyclable aminocatalyst for the enantioselective synthesis of γ-nitroketones by conjugate addition

✍ Scribed by Maurizio Benaglia; Mauro Cinquini; Franco Cozzi; Alessandra Puglisi; Giuseppe Celentano


Book ID
104422487
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
113 KB
Volume
204-205
Category
Article
ISSN
1381-1169

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A new class of efficient poly(ethylene-glycol)-supported catalysts based on proline was designed to catalyze the asymmetric Michael addition of ketones to nitrostyrenes. Using 5 mol% of the best catalyst, the products of the Michael reactions were obtained in good yields (up to 94%), moderate to goo