𝔖 Bobbio Scriptorium
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Polyethylene glycol-grafted polystyrene particles

✍ Scribed by Meng, Fenghua ;Engbers, Gerard H. M. ;Feijen, Jan

Book ID
102294337
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
126 KB
Volume
70A
Category
Article
ISSN
0021-9304

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✦ Synopsis

Densely pegylated particles that can serve as a model system for artificial cells were prepared by covalently grafting amino polyethylene glycol (PEG, molecular weight 3400 or 5000) onto carboxyl polystyrene particles (PS-COOH) using carbodiimide chemistry. PEG-modified particles (PS-PEG) were characterized by determination of the PEG surface concentration, zeta-potential, size, and morphology. Under optimized grafting conditions, a dense "brush-like" PEG layer was formed. A PEG surface concentration of approximately 60 pmol/cm2, corresponding with an average distance between grafted PEG chains of approximately 17 A can be realized. It was shown that grafting of PEG onto PS-COOH reduced the adsorption of proteins from human plasma (85 vol %) in phosphate-buffered saline up to 90%.

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