Polyethylene Glycol for Fractionation and Crystallization of L-Asparaginase
โ Scribed by Dr. O. Wagner; Dr. K. Bauer; Dr. E. Irion; Dr. E. Rauenbusch; Dr. W. Kaufmann; Dr. A. Arens
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 245 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0044-8249
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## Abstract ## BACKGROUND Multiple myeloma remains an incurable disease. New agents are needed to improve therapy for patients with this disease. Previous investigators evaluated in vitro sensitivity of myeloma cells to polyethylene glycolโconjugated Lโasparaginase (PEGโLโasparaginase) using the h
The antineoplastic enzyme L-asparaginase is commonly used for the induction of remission in acute lymphoblastic leukemia (ALL). There is no simple method available for measuring the activity of this highly toxic drug. We incubated L-asparaginase from Erwinia chrysanthemi with L-aspartic acid โค-(7-am