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polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice

✍ Scribed by C.L. Van Den Berg; G.N. Cox; C.A. Stroh; S.G. Hilsenbeck; C.-N. Weng; M.J. Mcdermott; D. Pratt; C.K. Osborne; E.B. Coronado-Heinsohn; D. Yee

Book ID: 117663822
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 827 KB
Volume: 33
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(97)00071-3

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## Abstract Insulin‐like growth factor binding protein‐1 (IGFBP‐1) is synthesized in the liver and regulates the mitogenic effects of the insulin‐like growth factors (IGFs). The evidence that IGFBP‐1 plays a role in hepatocarcinogenesis, however, is equivocal. We have, therefore, investigated the d