Poly(ether ester amide) Microspheres for Protein Delivery: Influence of Copolymer Composition on Technological and Biological Properties
✍ Scribed by Luisanna Ostacolo; Paola Russo; Giuseppe De Rosa; Maria Immacolata La Rotonda; Giovanni Maglio; Giuseppe Nese; Gianrico Spagnuolo; Sandro Rengo; Adriana Oliva; Fabiana Quaglia
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 250 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
The production of PEEA microspheres with potential as carriers for protein oral delivery is described. PEEAs with different hydrophilicity were synthesized and characterized. Experiments showed that an increase in copolymer hydrophilicity gave particles less prone to cell interaction. BSA release profiles from PEEA microspheres demonstrated that an increase in polymer hydrophilicity was useful in limiting protein burst and modulating drug delivery rate by increasing PEEA degradability. These results show that fine‐tuning of the hydrophilic/hydrophobic properties of PCL is essential for the formulation protein‐loaded microspheres with specific properties.
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