Polyelectrolyte Complexes Based on (Quaternized) Poly[(2-dimethylamino)ethyl methacrylate]: Behavior in Contact with Blood
✍ Scribed by Elena Yancheva; Dilyana Paneva; Dobri Danchev; Laetitia Mespouille; Philippe Dubois; Nevena Manolova; Iliya Rashkov
- Book ID
- 102933741
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 625 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Polyelectrolyte complexes (PECs) between (quaternized) poly[2‐(dimethylamino)ethyl methacrylate] (PDMAEMA) and (crosslinked) N‐carboxyethylchitosan (CECh) or poly(2‐acrylamido‐2‐methylpropane sodium sulfonate) (PAMPSNa) were prepared and characterized in terms of their stability, equilibrium water content, and surface morphology. The evaluation of the behavior of the studied PECs in contact with blood revealed that the (crosslinked) CECh/(quaternized) PDMAEMA complexes had lost the inherent PDMAEMA cytotoxicity but still preserved haemostatic activity. In contrast, the complex formation between (quaternized) PDMAEMA and PAMPSNa allowed the preparation of materials with improved blood compatibility.
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