Polyelectrolyte Complex Films Derived from Polyethyleneoxide-Maleic Acid Copolymer and Chitosan: Preparation and Characterization

✍ Scribed by Yoshitsune Shin-Ya; Hideo Tsurushima; Taro Tsurumi; Toshio Kajiuchi; Kam W. Leong

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 145 KB
• Volume: 4
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200300110

✦ Synopsis

Abstract

Summary: Polyelectrolyte complex films were prepared with polyethyleneoxide‐maleic acid copolymer and chitosan using a casting/solvent evaporation method. The films were examined in terms of their IR spectra, surface and cross‐section morphologies, cytotoxicity, and swelling behavior at different pH levels. To assess the potential of these films as a biomedical device, the profiles of the release of model drug from the CS/PEOMA films were examined at pH 4.8. The surface morphology of the films was quite smooth and uniform, and the cross‐sectional morphology was dense and homogeneous. The swelling behaviors of CS/PEOMA films were found to depend on the pH of the solution as well as on the CS/PEOMA composition. Drug release from different CS/PEOMA films at pH 4.8 was found to be dependent on film composition. The results showed the potential applicability of CS/PEOMA film as a drug delivery vehicle.

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