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Polycyclic Aromatic Hydrocarbons Decrease Intracellular Glutathione Levels in the A20.1 Murine B Cell Lymphoma

✍ Scribed by Jane W. Yuan; James A. Krieger; Kirk R. Maples; Jerry L. Born; Scott W. Burchiel


Book ID
115608363
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
368 KB
Volume
23
Category
Article
ISSN
0272-0590

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a