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Polycyclic aromatic hydrocarbon metabolizing cytochrome P450s in freshly prepared uncultured rat blood lymphocytes

✍ Scribed by Kumar Saurabh; Amit Sharma; Sanjay Yadav; Devendra Parmar

Book ID: 113489080
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 188 KB
Volume: 79
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2009.11.021

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a