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Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages

✍ Scribed by Sienerth, Arnold R; Scheuermann, Christian; Galmiche, Antoine; Rapp, Ulf R; Becker, Matthias

Book ID
120439840
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
344 KB
Volume
89
Category
Article
ISSN
0818-9641

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## Abstract Ligation of Toll‐like receptors (TLR) on macrophages induces cytokines and mediators important for the control of pathogens. Macrophage activation has to be tightly controlled to prevent hyper‐inflammation. Accordingly, the hallmarks of TLR‐triggered signaling, nuclear translocation of