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Polyclonal T-Cell Responses to Cytochrome P450IID6 Are Associated With Disease Activity in Autoimmune Hepatitis Type 2

✍ Scribed by Yun Ma; Dimitrios P. Bogdanos; Munther J. Hussain; James Underhill; Sanjay Bansal; Maria Serena Longhi; Paul Cheeseman; Giorgina Mieli–Vergani; Diego Vergani


Book ID
119759026
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
995 KB
Volume
130
Category
Article
ISSN
0016-5085

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Cytochrome P450IID6-specific CD8 T cell
✍ Maria Serena Longhi; Munther J. Hussain; Dimitrios P. Bogdanos; Alberto Quaglia; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 697 KB

Autoimmune hepatitis type 2 (AIH-2) is a severe organ-specific disorder characterized by liver kidney microsomal antibody type 1 targeting cytochrome P4502D6 (CYP2D6). Growing evidence implicates the involvement of CD8 T cell immune responses in its pathogenesis. We investigated CYP2D6-specific CD8