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Polyclonal B cell activation in paracoccidioidomycosis

โœ Scribed by Dumith Chequer-Bou-Habib; Claudio Daniel-Ribeiro; Dalma M. Banic; Antonio C. Franciscone Valle; Bernardo Galvao-Castro


Publisher
Springer Netherlands
Year
1989
Tongue
English
Weight
354 KB
Volume
108
Category
Article
ISSN
0301-486X

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โœฆ Synopsis


Paracoccidioidomycosis (PCM) is often associated with hypergammaglobulinemia and increased serum levels of circulating immune complexes (CIC). In order to investigate whether polyclonal B lymphocyte activation (PBA) is a current process in PCM, we measured the numbers of IgG secreting cells (IgG SC) in the peripheral blood of 16 patients and of 8 healthy controls. The numbers of IgG SC were found to be significantly elevated in PCM patients. We also observed increased serum levels of IgG, IgA and CIC. These data reflect an activation of B lymphocytes in PCM patients.


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