Polychlorinated biphenyls release insulin from RINm5F cells
β Scribed by Lawrence J. Fischer; Hui-Ren Zhou; Margaret A. Wagner
- Book ID
- 117174725
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 690 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0024-3205
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It has been proposed that mastoparan (INLKALAALAKKIL) and other mast cell secretagogues such as substance P (SP) or compound 48/80 act by direct activation of the pertussis toxin (PTX)-sensitive G-proteins in intact cells. Here we have investigated whether or not the antagonists of SP, [D-Trp7,9,10]
## ABSTRACE The clonal insulin producing cell line RINm5F was evaluated as a model for the action of cyproheptadine (CPH)-like diabetogenic compounds in the rat pancreas. Treatment with 10 & l CPH and selected structural analogs under culture conditions produced a progressive loss of cellular insu