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Polycarpine dihydrochloride: A cytotoxic dimeric disulfide alkaloid from the indian ocean ascidian Polycarpa clavata

โœ Scribed by Heonjoong Kang; William Fenical


Book ID
103410124
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
275 KB
Volume
37
Category
Article
ISSN
0040-4039

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Polycarpine 1, a highly cytotoxic marine natural product, has been synthesized in three steps from p-metho..xyphenacyl bromide 4\_ in 57% overall yield. The key reaction for construction of the synunetrically substituted disulfide linkage of polycarpine is the treatment of 2-amino-4-(4-methox3~pheny