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Polyamine and ifenprodil interactions with the NMDA receptor's glycine site

โœ Scribed by Richard W. Ransom


Book ID
113398187
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
492 KB
Volume
208
Category
Article
ISSN
0922-4106

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Recent work has shown that kynurenic acid and several quinoxaline derivatives act as non-competitive NMDA receptor antagonists by binding to the glycine site associated with this receptor. In this study, we have tested the effect of the most potent and selective of these compounds, 7-chlorokynurenic