Poly(amidoamine)s with 2-Dithiopyridine Side Substituents as Intermediates to Peptide–Polymer Conjugates

✍ Scribed by Elisabetta Ranucci; Paolo Ferruti; Marco Alessandro Suardi; Amedea Manfredi

• Book ID: 102495423
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 148 KB
• Volume: 28
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200700139

✦ Synopsis

Abstract

Cystamine, when employed as a cross‐linking agent, leads to poly(amidoamine) networks, which on reaction with 2,2′‐dithiodipyridine turn into linear poly(amidoamine)s with side dithiopyridyl groups that easily undergo exchange reactions with reduced L‐glutathione, a model thiol‐containing biologically active peptide. The resultant products represent the first examples of soluble poly(amidoamine)–peptide conjugates in which the peptide moieties are linked to the polymer chain by SS bonds stable in blood, but cleavable inside cells.

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