Polyamide layer chromatography of sulfonamides

✍ Scribed by Yau-Tang Lin; Kung-Tsung Wang; Tsai-I Yang

• Book ID: 104146562
• Publisher: Elsevier Science
• Year: 1965
• Tongue: English
• Weight: 978 KB
• Volume: 20
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)97472-2

✦ Synopsis

NOTES

procedure. Thin-layer chromatography allow s a rapid screening of many solutions for evidence of degradation of the preservative materials. The reader should refer to information published elsewhere 1 for a further discussion regarding the complexity of detecting the presence of degradation products in samples of methyl +hydroxybenzoate.

concl?acsions

Using the thin-layer chromatographic procedures described here to obtain additional evidence, the degradation products of methyl +hydroxybenzoate were definitely proved to be $-hydroxybenzoic acid and phenol. Typical one-dimensional, chromatographic results for several solutions which had undergone partial degradation are shown in Fig. 3. The procedures described here are useful for rapidly de_: tecting breakdown of the esters to p-hydroxybenzoic acid and should prove useful for screening large numbers of solutions for evidence of degradation.